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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC6A4 All Species: 24.55
Human Site: S611 Identified Species: 49.09
UniProt: P31645 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P31645 NP_001036.1 630 70325 S611 F K E R I I K S I T P E T P T
Chimpanzee Pan troglodytes XP_001135066 630 70262 S611 F K E R I I K S I T P E T P T
Rhesus Macaque Macaca mulatta Q9MYX0 630 70239 S611 F K E R I I K S I T P E T P T
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q60857 630 70129 S611 L K E R I I K S I T P E T P T
Rat Rattus norvegicus P31652 630 70153 S611 L K E R I I K S I T P E T P T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508462 865 94609 C839 L R E R L A Y C L T P E N E H
Chicken Gallus gallus NP_998737 670 74409 S651 L K E R I L K S I T P E T A T
Frog Xenopus laevis A7Y2W8 633 71004 S616 E K M K E D L S L T I Q G S N
Zebra Danio Brachydanio rerio NP_001035061 646 72103 G624 F Q Q R L L K G I T P E A P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P51905 622 69307 E602 G C R Q R L Q E S F Q P E D N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03614 615 69247 Y601 K R P N Q T E Y I P I P T T Q
Sea Urchin Strong. purpuratus XP_001204030 641 70931 A619 S L K E R F V A I T S P Q E H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 98.5 N.A. N.A. 92.8 91.7 N.A. 38.1 77.6 42.1 68.5 N.A. 50.4 N.A. 43.6 49.4
Protein Similarity: 100 99.5 99.5 N.A. N.A. 95.5 94.9 N.A. 52.9 85.2 60.8 80.6 N.A. 66.9 N.A. 63.3 66.6
P-Site Identity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 33.3 80 20 53.3 N.A. 0 N.A. 13.3 13.3
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 53.3 86.6 40 80 N.A. 20 N.A. 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 9 0 9 0 0 0 0 9 9 0 % A
% Cys: 0 9 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % D
% Glu: 9 0 59 9 9 0 9 9 0 0 0 67 9 17 0 % E
% Phe: 34 0 0 0 0 9 0 0 0 9 0 0 0 0 0 % F
% Gly: 9 0 0 0 0 0 0 9 0 0 0 0 9 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 % H
% Ile: 0 0 0 0 50 42 0 0 75 0 17 0 0 0 0 % I
% Lys: 9 59 9 9 0 0 59 0 0 0 0 0 0 0 0 % K
% Leu: 34 9 0 0 17 25 9 0 17 0 0 0 0 0 0 % L
% Met: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 0 0 0 0 0 0 9 0 17 % N
% Pro: 0 0 9 0 0 0 0 0 0 9 67 25 0 50 0 % P
% Gln: 0 9 9 9 9 0 9 0 0 0 9 9 9 0 9 % Q
% Arg: 0 17 9 67 17 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 0 0 0 0 0 0 59 9 0 9 0 0 9 0 % S
% Thr: 0 0 0 0 0 9 0 0 0 84 0 0 59 9 50 % T
% Val: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 9 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _